The long-awaited season opener has finally arrived as the Los Angeles Rams kick off their 2026 campaign against the San Francisco 49ers in a historic, first-ever regular season game in Melbourne, Australia. With 64% of the market backing the Rams outright on Kalshi, the real betting value sits with the spread at -3.5. Despite Aaron Donald staying behind in California to continue his ramp-up, the debut of reigning Defensive Player of the Year Myles Garrett—alongside new defensive backs Trent McDuffie and Jaylen Watson—gives Los Angeles an immediate defensive edge to attack San Francisco's offensive line. On the player props side, early-season lines offer incredible spot value before market adjustments take over in Week 2. Kyren Williams enters the opener coming off a dominant stretch where he cleared 70 combined rushing and receiving yards in six consecutive regular season games and two of three playoff appearances to close out last year. Meanwhile, star receiver Mike Evans faces a prime fade candidate on his line of under 50 receiving yards; adjusting to a new system alongside Brock Purdy while battling a lingering groin injury, Evans will draw heavy coverage from corner Jaylen Watson. Finally, Christian McCaffrey remains one of the safest anytime touchdown plays on the board, offering a strong return after racking up 17 total touchdowns last season.